Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.40 |
| ▸ | FAP | Q12884 | 4/20 | 0.40 |
| ▸ | PREP | P48147 | 2/20 | 0.37 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28132789 | 0.85 | DPP4 (0.47) | DPP4DPP8DPP9HCRTR2 | |
| SCHEMBL2455912 | 0.85 | DPP4 (0.47) | DPP4DPP8DPP9HCRTR2 | |
| Hydrochloric Acid SCHEMBL14737849 | 0.84 | DPP4 (0.46) | DPP4DPP8DPP9HCRTR2ARG1 | |
| SCHEMBL19981814 | 0.83 | DPP4 (0.55) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL14790967 | 0.81 | CHRNB2 (0.52) | DPP4HCRTR2 | |
| SCHEMBL28133450 | 0.81 | DPP4 (0.51) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL14655442 | 0.81 | DPP4 (0.51) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL16665410 | 0.79 | JAK2 (0.34) | DPP4HCRTR2 | |
| SCHEMBL15203524 | 0.78 | DPP4 (0.56) | DPP4DPP7DPP8DPP9HCRTR2 | |
| SCHEMBL14737248 | 0.77 | DPP4 (0.40) | DPP4DPP7DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078802-A1 | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-14 | — | — | WO | disclosed |