Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846655 | 0.85 | HPGD (0.50) | RAB9ALMNAMEN1KMT2AGSK3B | |
| SCHEMBL1024045 | 0.83 | RAB9A (0.51) | RAB9ALMNAMEN1KMT2AKDM4E | |
| SCHEMBL404490 | 0.81 | ERCC5 (0.61) | RAB9ALMNAMEN1KMT2AGSK3B | |
| SCHEMBL29391618 | 0.81 | ERCC5 (0.61) | RAB9ALMNAMEN1KMT2AGSK3B | |
| SCHEMBL405443 | 0.81 | MEN1 (0.62) | RAB9ALMNAMEN1KMT2AGSK3B | |
| SCHEMBL29670000 | 0.81 | MEN1 (0.62) | RAB9ALMNAMEN1KMT2AGSK3B | |
| SCHEMBL1024674 | 0.80 | RAB9A (0.49) | RAB9ALMNAMEN1KMT2AKDM4E | |
| SCHEMBL3233653 | 0.79 | CSNK2A1 (0.60) | RAB9ALMNAMEN1KMT2AGSK3B | |
| SCHEMBL31602938 | 0.79 | CSNK2A1 (0.60) | RAB9ALMNAMEN1KMT2AGSK3B | |
| SCHEMBL9926134 | 0.79 | ALDH1A1 (0.56) | KMT2AGSK3BPOLBERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023567-B2 | Imidazole and thiazole compositions for modifying biological signaling | OHIO UNIVERSITY (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170210737-A1 | IMIDAZOLE AND THIAZOLE COMPOSITIONS FOR MODIFYING BIOLOGICAL SIGNALING | OHIO UNIVERSITY (US) | 2017-07-27 | — | — | US | disclosed |
| US-20170196845-A1 | PREVENTION AND TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE | OHIO UNIVERSITY (US) | 2017-07-13 | — | — | US | disclosed |
| US-20150210669-A1 | COMPOUND FOR THE TREATMENT OF TUMOURS AND TUMOUR METASTASES | SIENA BIOTECH S.P.A. (IT) | 2015-07-30 | — | — | US | disclosed |
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| WO-2012076413-A1 | COMPOUND FOR THE TREATMENT OF TUMOURS AND TUMOUR METASTASES | SIENA BIOTECH S.P.A. (IT) | 2012-06-14 | — | — | WO | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210669-A1 | COMPOUND FOR THE TREATMENT OF TUMOURS AND TUMOUR METASTASES | SMO, SHH, GLI1 | RAB9A 1051/4885LMNA 4727/4885MEN1 615/4885 |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | PDE3B, PDE5A, PDE2A | RAB9A 2507/4885LMNA 2086/4885MEN1 2661/4885 |
| US-20170196845-A1 | PREVENTION AND TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE | FABP1, LIPC, SLC10A1 | RAB9A 2970/4885LMNA 1257/4885MEN1 4206/4885 |
| US-20170210737-A1 | IMIDAZOLE AND THIAZOLE COMPOSITIONS FOR MODIFYING BIOLOGICAL SIGNALING | FGFR1, TYRO3, STAT6 | RAB9A 3095/4885LMNA 3744/4885MEN1 1937/4885 |
| US-10023567-B2 | Imidazole and thiazole compositions for modifying biological signaling | FGFR1, TYRO3, STAT6 | RAB9A 3095/4885LMNA 3744/4885MEN1 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.