Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643532 | 0.86 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL9902960 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL643065 | 0.74 | SORT1 (0.49) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL1793961 | 0.71 | ALDH1A1 (0.67) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL4649906 | 0.70 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL28579350 | 0.70 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL7677575 | 0.69 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL711082 | 0.68 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| SCHEMBL4081642 | 0.68 | ALDH1A1 (1.00) | ALDH1A1KDM4EKMT2ASMN1; SMN2POLB | |
| Dimethylamine SCHEMBL28589149 | 0.67 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2010520-B1 | HETEROBICYCLIC AMIDES FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PROD INC (US) | 2012-09-12 | — | — | EP | disclosed |
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |