Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 2/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903836 | 0.89 | HTR6 (0.42) | HTR6HTR2AGRM5HTR1ADRD2 | |
| SCHEMBL9903819 | 0.89 | HTR6 (0.45) | HTR6HTR2AGRM5HTR1ADRD2 | |
| SCHEMBL9903397 | 0.88 | HTR6 (0.41) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3136898 | 0.86 | HTR6 (0.60) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL9903925 | 0.85 | HTR6 (0.43) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL9903063 | 0.84 | HTR6 (0.43) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL9903823 | 0.83 | GRM5 (0.43) | HTR6HTR2AGRM5HTR1ADRD2 | |
| SCHEMBL9902745 | 0.82 | HTR6 (0.66) | HTR6HTR2AGRM5DRD2HTR7 | |
| SCHEMBL9903832 | 0.82 | KHK (0.42) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3561220 | 0.82 | HTR6 (0.69) | HTR6HTR2AGRM5HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956004-B1 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |