Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.38 |
| ▸ | GHSR | Q92847 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902830 | 0.88 | HTR6 (0.48) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9903819 | 0.86 | HTR6 (0.45) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9903836 | 0.83 | HTR6 (0.42) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL5072337 | 0.83 | HTR6 (0.56) | HTR6PIK3CAAKR1B1KDM4EHTR1A | |
| SCHEMBL5072339 | 0.83 | HTR6 (0.56) | HTR6PIK3CAAKR1B1KDM4EHTR1A | |
| SCHEMBL17580665 | 0.83 | PIK3CA (0.42) | HTR6PIK3CAAKR1B1TRPV1KDM4E | |
| SCHEMBL17580765 | 0.82 | TRPV1 (0.39) | HTR6PIK3CAAKR1B1TRPV1KDM4E | |
| SCHEMBL9903063 | 0.82 | HTR6 (0.43) | HTR6PIK3CAALDH1A1HTR1ADRD2 | |
| SCHEMBL9903823 | 0.81 | GRM5 (0.43) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9903925 | 0.81 | HTR6 (0.43) | HTR6HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956004-B1 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |