Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | FABP2 | P12104 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12152596 | 0.87 | BACE1 (0.47) | BACE1NPC1POLBMEN1KMT2A | |
| SCHEMBL20998254 | 0.85 | ELANE (0.52) | BACE1NPC1POLBMEN1KMT2A | |
| SCHEMBL26633310 | 0.84 | MEN1 (0.50) | BACE1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL16604314 | 0.84 | LMNA (0.42) | BACE1NPC1POLBKDM4EGLA | |
| SCHEMBL3824865 | 0.83 | BACE1 (0.63) | BACE1NPC1POLBMEN1KMT2A | |
| SCHEMBL1543293 | 0.83 | ELANE (0.51) | MEN1KMT2AMAPTSMN1; SMN2PTGS1 | |
| SCHEMBL16850583 | 0.83 | LMNA (0.44) | BACE1NPC1POLBMEN1KMT2A | |
| SCHEMBL18473043 | 0.83 | ELANE (0.50) | BACE1NPC1POLBMEN1KMT2A | |
| SCHEMBL8984617 | 0.83 | ELANE (0.50) | BACE1NPC1POLBMEN1KMT2A | |
| SCHEMBL16748115 | 0.83 | BACE1 (0.43) | BACE1KDM4EGLALMNAAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463263-B1 | ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME | RIKEN (JP) | 2014-04-23 | — | — | EP | disclosed |
| EP-2463263-A1 | ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME | Riken (JP) | 2012-06-13 | — | — | EP | disclosed |