Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.37 |
| ▸ | GRM5 | P41594 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902355 | 1.00 | GRM2 (0.39) | GRM2SCD5GRM5KDM4ESMN1; SMN2 | |
| SCHEMBL9902640 | 0.86 | BRD4 (0.40) | GRM2SCD5GRM5 | |
| SCHEMBL9903595 | 0.82 | GRM2 (0.38) | GRM2KDM4ESMN1; SMN2RIPK1PAX8 | |
| SCHEMBL9903489 | 0.82 | GRM2 (0.38) | GRM2KDM4ESMN1; SMN2RIPK1PAX8 | |
| SCHEMBL9902353 | 0.80 | RIPK1 (0.43) | SCD5KDM4ESMN1; SMN2SCDRIPK1 | |
| SCHEMBL9903354 | 0.75 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| SCHEMBL9902651 | 0.73 | HTR7 (0.35) | GRM2KDM4ESMN1; SMN2CHRM3PAX8 | |
| SCHEMBL9903245 | 0.73 | HTR7 (0.35) | GRM2KDM4ESMN1; SMN2CHRM3PAX8 | |
| SCHEMBL9903873 | 0.73 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL9903405 | 0.72 | GPR35 (0.35) | SMN1; SMN2GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916549-B2 | Thienooxazepine derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-12-23 | — | — | US | disclosed |
| EP-2463290-B1 | THIENOOXAZEPINE DERIVATIVE | TAKEDA PHARMACEUTICAL (JP) | 2014-03-05 | — | — | EP | disclosed |
| US-20120196848-A1 | THIENOOXAZEPINE DERIVATIVE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-08-02 | — | — | US | disclosed |
| EP-2463290-A1 | THIENOOXAZEPINE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196848-A1 | THIENOOXAZEPINE DERIVATIVE | HTR2C, HTR2B, HTR2A | GRM2 147/4885SCD5 1938/4885GRM5 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.