Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15082923 | 0.83 | MAPT (0.61) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31481963 | 0.83 | MAPT (0.57) | MAPTALDH1A1HTTTDP1ATM | |
| SCHEMBL3512219 | 0.83 | MAPT (0.57) | MAPTALDH1A1HTTTDP1ATM | |
| SCHEMBL989963 | 0.82 | MAPT (0.60) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28694709 | 0.82 | MAPT (0.60) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL991433 | 0.82 | MAPT (0.60) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7805715 | 0.82 | MAPT (0.60) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10485638 | 0.81 | ATM (0.45) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27864294 | 0.81 | MAPT (0.56) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3515437 | 0.80 | HCAR3 (0.52) | MAPTALDH1A1TDP1ATMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940889-B2 | Process for producing benzo [b] [1,4] diazepine-2,4-dione compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-01-27 | — | — | US | disclosed |
| US-8796447-B2 | Process for producing benzo[B][1,4]diazepine-2,4-dione compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-08-05 | — | — | US | disclosed |
| US-20140194621-A1 | PROCESS FOR PRODUCING BENZO [B] [1,4] DIAZEPINE-2, 4-DIONE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-07-10 | — | — | US | disclosed |
| US-8574467-B1 | Benzo-fused heterocyclic chromophores for nonlinear optical devices | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-11-05 | — | — | US | disclosed |
| US-8574468-B1 | Benzo-fused heterocyclic chromophores for nonlinear optical devices | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-11-05 | — | — | US | disclosed |
| US-8574467-B1 | Benzo-fused heterocyclic chromophores for nonlinear optical devices | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-11-05 | — | — | US | disclosed |
| US-8574468-B1 | Benzo-fused heterocyclic chromophores for nonlinear optical devices | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-11-05 | — | — | US | disclosed |
| EP-2468733-A1 | PROCESS FOR PRODUCING BENZO[B][1,4]DIAZEPINE-2,4-DIONE COMPOUND | Otsuka Pharmaceutical Co., Ltd. (JP) | 2012-06-27 | — | — | EP | disclosed |
| US-20120149899-A1 | PROCESS FOR PRODUCING BENZO[B][1,4]DIAZEPINE-2,4-DIONE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
| US-7863310-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2011-01-04 | — | — | US | disclosed |
| US-20080227839-A1 | Kinase Inhibitors | ELI LILLY AND COMPANY | 2008-09-18 | — | — | US | disclosed |
| EP-1720862-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005080380-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149899-A1 | PROCESS FOR PRODUCING BENZO[B][1,4]DIAZEPINE-2,4-DIONE COMPOUND | KCNH1, KCNB2, KCNJ2 | MAPT 4600/4885ALDH1A1 334/4885CYP1A2 28/4885 |
| US-20140194621-A1 | PROCESS FOR PRODUCING BENZO [B] [1,4] DIAZEPINE-2, 4-DIONE COMPOUND | KCNH1, KCNB2, KCNB1 | MAPT 4472/4885ALDH1A1 432/4885CYP1A2 25/4885 |
| US-20080227839-A1 | Kinase Inhibitors | ABL1, MAP3K20, MAP3K19 | MAPT 2603/4885ALDH1A1 3631/4885CYP1A2 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.