Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.78 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.78 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.78 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.78 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.78 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.78 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.78 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9111491 | 1.00 | ALOX15 (0.78) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| SCHEMBL9110299 | 1.00 | ALOX15 (0.78) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| SCHEMBL7553077 | 0.90 | PDK1 (0.80) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| SCHEMBL7553072 | 0.90 | PDK1 (0.80) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| Methyl Abietate SCHEMBL316225 | 0.89 | ALOX15 (0.78) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| Methyl Abietate SCHEMBL316227 | 0.89 | ALOX15 (0.78) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| Methyl Abietate SCHEMBL1527667 | 0.89 | ALOX15 (0.78) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| Methyl Abietate SCHEMBL316226 | 0.89 | ALOX15 (0.78) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| SCHEMBL11479951 | 0.89 | HSD17B10 (0.74) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 | |
| SCHEMBL11479944 | 0.89 | HSD17B10 (0.74) | ALOX15CYP3A4HSD17B10LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078667-A9 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-08-16 | — | — | WO | claimed |
| EP-2648706-A2 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | The Penn State Research Foundation (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078667-A2 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-06-14 | — | — | WO | disclosed |