Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19656029 | 0.89 | GFER (0.42) | MAPTSMN1; SMN2ALDH1A1GFERLMNA | |
| SCHEMBL9905570 | 0.85 | MTNR1B (0.49) | MTNR1BMTNR1AMAPTRAB9ANPC1 | |
| SCHEMBL15534678 | 0.85 | KMT2A (0.37) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL15303642 | 0.84 | AAK1 (0.37) | ALDH1A1LMNAMEN1KMT2AHTR2C | |
| SCHEMBL15306197 | 0.84 | AAK1 (0.37) | ALDH1A1LMNAMEN1KMT2AHTR2C | |
| SCHEMBL15303403 | 0.83 | GABRA5 (0.35) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL20598035 | 0.83 | GABRA5 (0.35) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL16659201 | 0.81 | KMT2A (0.39) | MAPTRAB9ANPC1TP53GAA | |
| SCHEMBL23279398 | 0.80 | KEAP1 (0.32) | MAPTRAB9ANPC1KDM4EHTR2C | |
| SCHEMBL16193648 | 0.79 | KMT2A (0.32) | MAPTALDH1A1GFERMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |