Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 2/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642146 | 1.00 | RAB9A (0.40) | RAB9ALMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL2644681 | 0.90 | GCK (0.39) | RAB9ASMN1; SMN2MAPTTSHRHPGD | |
| SCHEMBL643693 | 0.85 | LMNA (0.51) | RAB9ALMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL2645432 | 0.82 | LDHA (0.40) | RAB9ALMNASMN1; SMN2MAPTHPGD | |
| SCHEMBL644402 | 0.80 | GCK (0.56) | RAB9ANPC1GCKRARARARB | |
| SCHEMBL642200 | 0.79 | MAPT (0.41) | RAB9ALMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL642767 | 0.79 | MAPT (0.41) | RAB9ALMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL2644915 | 0.78 | GCK (0.36) | HPGDGCKRARARARBFFAR4 | |
| SCHEMBL643590 | 0.74 | MAOB (0.49) | RAB9ASMN1; SMN2HPGDKMT2ANPC1 | |
| SCHEMBL642852 | 0.74 | SCN9A (0.41) | RAB9ALMNASMN1; SMN2MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |