Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.64 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20585385 | 1.00 | ABCG2 (0.64) | ABCG2NFE2L2CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL9907008 | 0.90 | HDAC1 (0.63) | ABCG2NFE2L2CYP1A1CYP1B1SMN1; SMN2 | |
| SCHEMBL2744097 | 0.89 | ABCG2 (0.73) | ABCG2NFE2L2CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL2743991 | 0.89 | ABCG2 (0.73) | ABCG2NFE2L2CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL9907023 | 0.88 | ABCG2 (0.64) | ABCG2NFE2L2CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL14571866 | 0.87 | NFE2L2 (0.80) | NFE2L2CYP1A1CYP1A2CYP2D6NPC1 | |
| SCHEMBL10468803 | 0.85 | ABCG2 (0.64) | ABCG2NFE2L2CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL10468802 | 0.85 | ABCG2 (0.64) | ABCG2NFE2L2CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL285232 | 0.84 | ABCG2 (0.71) | ABCG2NFE2L2CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL285231 | 0.84 | ABCG2 (0.71) | ABCG2NFE2L2CYP1A1CYP1B1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117907-B2 | Curcuminoid-inspired synthetic compounds as anti-tumor agents | UNIVERSITY OF NORTH FLORIDA BOARD OF TRUSTEES (US) | 2021-09-14 | — | — | US | disclosed |
| US-20210087208-A1 | NOVEL CURCUMINOID-INSPIRED SYNTHETIC COMPOUNDS AS ANTI-TUMOR AGENTS | UNIVERSITY OF NORTH FLORIDA BOARD OF TRUSTEES (US) | 2021-03-25 | — | — | US | disclosed |
| US-10934241-B2 | Curcuminoid-inspired synthetic compounds as anti-tumor agents | UNIVERSITY OF NORTH FLORIDA BOARD OF TRUSTEES (US) | 2021-03-02 | — | — | US | disclosed |
| US-8198323-B2 | Curcumin analogues and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-06-12 | — | — | US | disclosed |
| US-8198323-B2 | Curcumin analogues and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-06-12 | — | — | US | disclosed |
| US-20100197784-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | The University of North Carlina at Chapel Hill (US) | 2010-08-05 | — | — | US | disclosed |
| US-20100197784-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | The University of North Carlina at Chapel Hill (US) | 2010-08-05 | — | — | US | disclosed |
| US-7709535-B2 | Curcumin analogues and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709535-B2 | Curcumin analogues and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-05-04 | — | — | US | disclosed |
| US-20080161391-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA (US) | 2008-07-03 | — | — | US | disclosed |
| US-20080161391-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA (US) | 2008-07-03 | — | — | US | disclosed |
| US-20080146660-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146660-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-06-19 | — | — | US | disclosed |
| US-7355081-B2 | androgen receptor antagonists; certain cancers, baldness, hirsutism, behavioral disorders, acne, and inhibition of spermatogenesis if so desired | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-04-08 | — | — | US | disclosed |
| US-7355081-B2 | androgen receptor antagonists; certain cancers, baldness, hirsutism, behavioral disorders, acne, and inhibition of spermatogenesis if so desired | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146660-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | AR, NR5A1, BRDT | ABCG2 679/4885NFE2L2 1264/4885CYP1A1 353/4885 |
| US-11117907-B2 | Curcuminoid-inspired synthetic compounds as anti-tumor agents | FOXO3, IKZF3, FOXO1 | ABCG2 445/4885NFE2L2 92/4885CYP1A1 1159/4885 |
| US-20210087208-A1 | NOVEL CURCUMINOID-INSPIRED SYNTHETIC COMPOUNDS AS ANTI-TUMOR AGENTS | IKZF3, FOXO3, FOXO1 | ABCG2 609/4885NFE2L2 68/4885CYP1A1 1161/4885 |
| US-20080161391-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | AR, NR5A1, BRDT | ABCG2 679/4885NFE2L2 1264/4885CYP1A1 353/4885 |
| US-10934241-B2 | Curcuminoid-inspired synthetic compounds as anti-tumor agents | FOXO3, FOXO1, IKZF3 | ABCG2 1020/4885NFE2L2 204/4885CYP1A1 1653/4885 |
| US-20100197784-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | AR, NR5A1, BRDT | ABCG2 679/4885NFE2L2 1264/4885CYP1A1 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.