Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907520 | 0.92 | HTR5A (0.53) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 | |
| SCHEMBL9909145 | 0.89 | HTR5A (0.50) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 | |
| SCHEMBL9907649 | 0.87 | HTR5A (0.54) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 | |
| SCHEMBL9907337 | 0.87 | HTR5A (0.51) | ALDH1A1L3MBTL1TP53HTR5AHPGD | |
| SCHEMBL15500532 | 0.87 | HTR5A (0.41) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 | |
| SCHEMBL9907526 | 0.84 | MAPT (0.52) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 | |
| SCHEMBL9909237 | 0.84 | HTR5A (0.55) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 | |
| SCHEMBL9907332 | 0.84 | HTR5A (0.64) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 | |
| SCHEMBL9907616 | 0.83 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1NPC1CYP1A2CYP2C9 | |
| SCHEMBL15500533 | 0.81 | HTR5A (0.45) | ALDH1A1TP53MAPTHTR5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | ALDH1A1 1799/4885L3MBTL1 3654/4885NPC1 753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.