Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.44 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | YWHAG | P61981 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907608 | 0.92 | HTR5A (0.72) | HTR5ATDP1IP6K1IP6K3IP6K2 | |
| SCHEMBL9907615 | 0.89 | HTR5A (0.59) | HTR5ATDP1IP6K1IP6K3IP6K2 | |
| SCHEMBL9907738 | 0.88 | HTR5A (0.58) | HTR5ATDP1IP6K1IP6K3IP6K2 | |
| SCHEMBL9909245 | 0.87 | HTR5A (0.57) | HTR5ATDP1ALDH1A1HPGDKDM4E | |
| SCHEMBL9907618 | 0.85 | HTR5A (0.55) | HTR5AALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL9907894 | 0.84 | HTR5A (0.87) | HTR5A | |
| SCHEMBL9907657 | 0.83 | HTR5A (0.56) | HTR5ATDP1IP6K1IP6K3IP6K2 | |
| SCHEMBL9907579 | 0.82 | LMNA (0.54) | HTR5ATDP1ALDH1A1HPGDKDM4E | |
| SCHEMBL9907631 | 0.81 | HTR5A (0.51) | HTR5ATDP1ALDH1A1HPGDKDM4E | |
| SCHEMBL9907620 | 0.81 | HTR5A (0.53) | HTR5ATDP1IP6K1IP6K3IP6K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | HTR5A 1/4885TDP1 964/4885IP6K1 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.