Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 6/20 | 0.45 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | TET3 | O43151 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907373 | 0.91 | HTR5A (0.50) | PLAUTTRHTR5APLA2G2DCSNK2A2 | |
| SCHEMBL9907318 | 0.89 | PLAU (0.50) | PLAUHTR5APLA2G2DCSNK2A2CSNK2B | |
| Hydrochloric Acid SCHEMBL9108278 | 0.88 | PLAU (0.49) | PLAUHTR5APLA2G2DCSNK2A2CSNK2B | |
| SCHEMBL12875031 | 0.84 | ALOX15 (0.45) | HTR5AKDM4CKDM4EKDM6BALDH1A1 | |
| SCHEMBL9907374 | 0.83 | PLAU (0.50) | PLAUTTRHTR5APLA2G2DGRIN2D | |
| SCHEMBL9907943 | 0.82 | HTR5A (0.69) | PLAUHTR5A | |
| SCHEMBL9907335 | 0.80 | PLAU (0.55) | PLAUPLA2G2DCSNK2A2CSNK2BGRIN2D | |
| SCHEMBL9907597 | 0.80 | TTR (0.45) | TTRHTR5APLA2G2DCSNK2A2CSNK2B | |
| SCHEMBL9907523 | 0.79 | HTR5A (0.69) | TTRHTR5ACSNK2A2CSNK2BPTPN1 | |
| SCHEMBL16502630 | 0.78 | PLA2G2D (0.46) | PLAUTTRPLA2G2DCSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | PLAU 3322/4885TTR 3634/4885HTR5A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.