Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | PDE2A | O00408 | 3/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907624 | 0.91 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1PDE2APDE10ARAB9A | |
| SCHEMBL9907548 | 0.89 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1PDE2APDE10ARAB9A | |
| SCHEMBL9907705 | 0.86 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1PDE2APDE10ARAB9A | |
| SCHEMBL9907721 | 0.86 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1PDE2APDE10ARAB9A | |
| SCHEMBL9107164 | 0.82 | ALDH1A1 (0.79) | ALDH1A1L3MBTL1PDE2APDE10ARAB9A | |
| SCHEMBL9907545 | 0.82 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1PDE2APDE10ARAB9A | |
| SCHEMBL15500555 | 0.81 | ESR2 (0.40) | ALDH1A1L3MBTL1PDE2APDE10ACYP1A2 | |
| SCHEMBL9907604 | 0.80 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1PDE2ARAB9ANPC1 | |
| SCHEMBL3321046 | 0.80 | FABP3 (0.56) | ALDH1A1L3MBTL1PDE2APDE10ARAB9A | |
| SCHEMBL9108374 | 0.80 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1PDE2APDE10ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | ALDH1A1 1799/4885L3MBTL1 3654/4885PDE2A 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.