Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.54 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 8/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907703 | 0.90 | MAP2K4 (0.54) | CSNK2A2CSNK2BMAP2K4HTR5AGABRA5 | |
| SCHEMBL9907701 | 0.88 | HTR5A (0.47) | MAP2K4HTR5AGABRA5DHODHMEN1 | |
| SCHEMBL9907514 | 0.86 | HTR5A (0.48) | CSNK2A2CSNK2BMAP2K4HTR5AGABRA5 | |
| SCHEMBL9907692 | 0.85 | HTR5A (0.55) | CSNK2A2CSNK2BMAP2K4HTR5AMAPT | |
| SCHEMBL9909264 | 0.85 | EGLN2 (0.45) | CSNK2A2CSNK2BMAP2K4HTR5A | |
| SCHEMBL9907518 | 0.85 | MAP2K4 (0.44) | CSNK2A2CSNK2BMAP2K4HTR5AGABRA5 | |
| SCHEMBL9907713 | 0.85 | CDH1 (0.51) | CSNK2A2CSNK2BMAP2K4HTR5ADHODH | |
| SCHEMBL9907754 | 0.84 | HTR5A (0.47) | CSNK2A2CSNK2BMAP2K4HTR5AMAPT | |
| SCHEMBL9908022 | 0.83 | MAP2K4 (0.52) | CSNK2A2CSNK2BMAP2K4HTR5AGABRA5 | |
| SCHEMBL9909280 | 0.83 | SCN9A (0.52) | CSNK2A2CSNK2BMAP2K4HTR5AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| WO-2011016504-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | CSNK2A2 4132/4885CSNK2B 4303/4885MAP2K4 3941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.