Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12095162 | 0.77 | NOTUM (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL991256 | 0.68 | PIK3CA (0.73) | PIK3CAPIK3CB | |
| SCHEMBL12555285 | 0.66 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17828247 | 0.66 | DYRK1A (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGDYRK1A | |
| SCHEMBL990752 | 0.65 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL13655404 | 0.65 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL11896939 | 0.65 | ALDH1A1 (0.36) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL990269 | 0.64 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL990778 | 0.62 | NOS3 (0.35) | PIK3CAAAK1 | |
| SCHEMBL988342 | 0.62 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |