Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990269 | 0.86 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL12836699 | 0.75 | NOTUM (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL1485245 | 0.74 | PIK3CA (0.46) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL13655337 | 0.73 | PIK3CA (0.76) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL989235 | 0.72 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL988342 | 0.71 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL990752 | 0.70 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL13655400 | 0.69 | PIK3CA (0.79) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL13655305 | 0.69 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGNOTUM | |
| SCHEMBL13655398 | 0.69 | PIK3CA (0.59) | PIK3CAPIK3CBNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |