Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | GRM5 | P41594 | 10/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378272 | 0.85 | GRM5 (0.42) | MAOBGRM5NPC1RAB9A | |
| SCHEMBL990822 | 0.83 | NPC1 (0.48) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990999 | 0.83 | GRM5 (0.56) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990361 | 0.82 | LMNA (0.50) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990881 | 0.82 | LMNA (0.50) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL1907158 | 0.82 | GRM5 (0.46) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL1907156 | 0.82 | GRM5 (0.46) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL2815651 | 0.82 | GRM5 (0.46) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990812 | 0.81 | RAB9A (0.55) | MAOBGRM5NPC1RAB9A | |
| SCHEMBL990340 | 0.81 | L3MBTL1 (0.59) | GRM5L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |