Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990768 | 1.00 | GRM5 (0.47) | GRM5L3MBTL1CHRM5HTR2B | |
| SCHEMBL991434 | 0.90 | GRM5 (0.45) | GRM5L3MBTL1 | |
| SCHEMBL990758 | 0.90 | GRM5 (0.45) | GRM5L3MBTL1 | |
| SCHEMBL990930 | 0.89 | GRM5 (0.47) | GRM5 | |
| SCHEMBL991428 | 0.89 | GRM5 (0.47) | GRM5 | |
| SCHEMBL990781 | 0.84 | ALDH1A1 (0.48) | GRM5L3MBTL1CHRM5 | |
| SCHEMBL990810 | 0.84 | ALDH1A1 (0.48) | GRM5L3MBTL1CHRM5 | |
| SCHEMBL4880266 | 0.83 | GRM5 (0.53) | GRM5CHRM5 | |
| SCHEMBL990772 | 0.83 | GRM5 (0.60) | GRM5L3MBTL1 | |
| SCHEMBL990045 | 0.82 | GRM5 (0.54) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |
| EP-2211859-A2 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS FOR THE TREATMENT OF PARKINSON'S DISEASE | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009047296-A2 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS FOR THE TREATMENT OP PARKINSON'S DISEASE | NOVARTIS AG (CH) | 2009-04-16 | — | — | WO | disclosed |