Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20746724 | 0.81 | TSHR (0.41) | LMNAF2TSHRTP53AKT1 | |
| SCHEMBL25969894 | 0.77 | LMNA (0.41) | LMNAF2TSHRTP53AKT1 | |
| SCHEMBL8246907 | 0.77 | ELANE (0.41) | TDP1PARP10MAPTKMT2AHSD17B10 | |
| SCHEMBL27552402 | 0.75 | TDP1 (0.49) | LMNAF2TSHRTP53TDP1 | |
| SCHEMBL1822836 | 0.74 | LMNA (0.64) | LMNAF2TSHRTP53TDP1 | |
| SCHEMBL3794632 | 0.74 | ELANE (0.53) | LMNAF2TSHRTP53TDP1 | |
| SCHEMBL21688900 | 0.74 | BCHE (0.55) | — | |
| SCHEMBL22407127 | 0.73 | LMNA (0.52) | LMNAF2TSHRTP53TDP1 | |
| SCHEMBL27825777 | 0.73 | LMNA (0.47) | LMNAF2TSHRTP53AKT1 | |
| SCHEMBL21064784 | 0.72 | LMNA (0.61) | LMNAF2TSHRTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198435-B2 | Crystal form of N-benzoyl-staurosporine | NOVARTIS AG (CH) | 2012-06-12 | — | — | US | disclosed |