Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | GAK | O14976 | 2/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.45 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.45 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9909208 | 0.90 | SCN9A (0.51) | SCN9AGAKRIPK2COQ8ANLK | |
| SCHEMBL9909299 | 0.86 | SCN9A (0.45) | SCN9AGAKRIPK2COQ8ANLK | |
| SCHEMBL12875034 | 0.82 | SCN9A (0.43) | SCN9AGAKRIPK2COQ8ANLK | |
| SCHEMBL9909213 | 0.81 | KDM4C (0.46) | SCN9AKDM4CCCNT1CDK9LMNA | |
| SCHEMBL9909265 | 0.81 | PDE5A (0.42) | SCN9AEGLN1CYP11B1CYP11B2PDE5A | |
| SCHEMBL9909160 | 0.80 | SLC22A12 (0.58) | KDM4CSLC22A12KDM5AKDM5B | |
| SCHEMBL16502436 | 0.80 | SLC22A12 (0.47) | SCN9AEGLN1CYP11B1CYP11B2SLC22A12 | |
| SCHEMBL16509459 | 0.80 | HTT (0.47) | SCN9AEGLN1CYP11B1CYP11B2SLC22A12 | |
| SCHEMBL9909257 | 0.78 | SLC22A12 (0.42) | SCN9AEGLN1CYP11B1CYP11B2SLC22A12 | |
| Hydrochloric Acid SCHEMBL18109880 | 0.76 | CA12 (0.53) | KDM4CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| EP-2463276-B1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2014-03-12 | — | — | EP | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| WO-2011016504-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | SCN9A 412/4885GAK 1532/4885RIPK2 2038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.