Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 18/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12874649 | 0.89 | HTR5A (0.46) | HTR5AKDM4EMAPK1NPSR1 | |
| SCHEMBL9907840 | 0.88 | HTR5A (0.63) | HTR5A | |
| SCHEMBL9907788 | 0.88 | HTR5A (0.69) | HTR5A | |
| SCHEMBL9907795 | 0.87 | HTR5A (0.58) | HTR5A | |
| SCHEMBL9907834 | 0.84 | HTR5A (0.61) | HTR5A | |
| SCHEMBL9909165 | 0.84 | LMNA (0.49) | HTR5AKDM4EMAPK1NPSR1 | |
| SCHEMBL9909219 | 0.83 | HTR5A (0.45) | HTR5A | |
| SCHEMBL9909210 | 0.83 | HTT (0.46) | KDM4EMAPK1NPSR1 | |
| SCHEMBL12874631 | 0.81 | HTR5A (0.52) | HTR5A | |
| SCHEMBL9907790 | 0.81 | HTR5A (0.62) | HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | HTR5A 1/4885KDM4E 1474/4885MAPK1 3555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.