Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1919031 | 0.91 | HDAC1 (0.51) | MAPTSMN1; SMN2ELOVL1ROCK1PARP1 | |
| SCHEMBL9910027 | 0.84 | GRM1 (0.43) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9910026 | 0.83 | ADORA3 (0.51) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1919490 | 0.81 | HDAC1 (0.52) | NPC1RAB9ASMN1; SMN2ELOVL1ROCK1 | |
| SCHEMBL1919049 | 0.80 | HDAC1 (0.53) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL12487245 | 0.78 | ELOVL1 (0.55) | MAPTNPC1RAB9ASMN1; SMN2ELOVL1 | |
| SCHEMBL2697136 | 0.78 | HDAC1 (0.44) | NPC1RAB9AELOVL1ROCK1PARP1 | |
| SCHEMBL5645472 | 0.77 | RAB9A (0.54) | MAPTNPC1RAB9ASMN1; SMN2ELOVL1 | |
| SCHEMBL5643715 | 0.77 | AR (0.54) | MAPTNPC1RAB9ASMN1; SMN2ELOVL1 | |
| SCHEMBL5645955 | 0.77 | RAB9A (0.54) | MAPTNPC1RAB9ASMN1; SMN2ELOVL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198299-B2 | Cycloalkylidene and heterocycloalkylidene inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-20120045412-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120045412-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC2 | MAPT 1634/4885NPC1 277/4885RAB9A 2514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.