Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12410346 | 0.92 | SIRT2 (0.36) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL13311607 | 0.90 | SIRT2 (0.39) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL277682 | 0.90 | SIRT2 (0.39) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL18470786 | 0.90 | SIRT2 (0.36) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL277487 | 0.89 | SIRT2 (0.40) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL13311697 | 0.88 | SIRT2 (0.41) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL12410282 | 0.88 | SIRT2 (0.35) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL14978142 | 0.87 | SIRT2 (0.36) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL12419151 | 0.85 | SIRT2 (0.38) | SIRT2SIRT1HDAC4EP300MEF2D | |
| SCHEMBL12419082 | 0.85 | SIRT2 (0.36) | SIRT2SIRT1HDAC4EP300MEF2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809489-B2 | Methods for preparing polymeric reagents and compositions of polymeric reagents | NEKTAR THERAPEUTICS (US) | 2014-08-19 | — | — | US | disclosed |
| US-20140044672-A1 | CONJUGATES OF A GM-CSF MOIETY AND A POLYMER | NEKTAR THERAPEUTICS (US) | 2014-02-13 | — | — | US | disclosed |
| US-20130253203-A1 | Methods for Preparing Polymeric Reagents and Compositions of Polymeric Reagents | NEKTAR THERAPEUTICS (US) | 2013-09-26 | — | — | US | disclosed |
| US-8293869-B2 | Polymer conjugates of GLP-1 | NEKTAR THERAPEUTICS (US) | 2012-10-23 | — | — | US | disclosed |
| US-8193306-B2 | Methods for preparing polymeric reagents and compositions of polymeric reagents | NEKTAR THERAPEUTICS (US) | 2012-06-05 | — | — | US | disclosed |
| US-20110171163-A1 | POLYMER CONJUGATES OF ZICONOTIDE PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110171161-A1 | POLYMER CONJUGATES OF PROTEGRIN PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20100256310-A1 | Methods for Preparing Polymeric Reagents and Compositions of Polymeric Reagents | NEKTAR THERAPEUTICS (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100210505-A1 | POLYMER CONJUGATES OF GLP-1 | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2010-08-19 | — | — | US | disclosed |
| US-7767784-B2 | Active carbonate esters of water-soluble polyoxyethylene glycol | NEKTAR THERAPEUTICS (US) | 2010-08-03 | — | — | US | disclosed |
| US-20080064851-A1 | Active carbonate esters of water-soluble polyoxyethylene glycol | NEKTAR THERAPEUTICS | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171163-A1 | POLYMER CONJUGATES OF ZICONOTIDE PEPTIDES | NGLY1, VIP, IAPP | SIRT2 2999/4885SIRT1 1782/4885HDAC4 1973/4885 |
| US-20100210505-A1 | POLYMER CONJUGATES OF GLP-1 | GLP1R, GIPR, NGLY1 | SIRT2 670/4885SIRT1 105/4885HDAC4 1798/4885 |
| US-20110171161-A1 | POLYMER CONJUGATES OF PROTEGRIN PEPTIDES | PSMG3, PSMB11, PSMC5 | SIRT2 2910/4885SIRT1 2889/4885HDAC4 4386/4885 |
| US-20140044672-A1 | CONJUGATES OF A GM-CSF MOIETY AND A POLYMER | CSF3R, GMFG, CSF1R | SIRT2 3614/4885SIRT1 3359/4885HDAC4 2889/4885 |
| US-20130253203-A1 | Methods for Preparing Polymeric Reagents and Compositions of Polymeric Reagents | SI, PHYKPL, PHOSPHO1 | SIRT2 4146/4885SIRT1 3161/4885HDAC4 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.