Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12973890 | 0.72 | MEN1 (0.53) | KDM4EALDH1A1NPC1HSD17B10GAA | |
| SCHEMBL2039989 | 0.71 | PDE10A (0.52) | KDM4EALDH1A1NPC1HSD17B10MEN1 | |
| SCHEMBL13403422 | 0.71 | BAZ2B (0.36) | KDM4EGAAL3MBTL1 | |
| SCHEMBL15001139 | 0.70 | KDM4E (0.50) | KDM4EALDH1A1ERCC1DNASE1FEN1 | |
| SCHEMBL3460157 | 0.70 | ATR (0.65) | KDM4EALDH1A1ERCC1DNASE1FEN1 | |
| SCHEMBL10168098 | 0.69 | ALDH1A1 (0.46) | KDM4EALDH1A1NPC1HSD17B10MEN1 | |
| SCHEMBL18460824 | 0.68 | RAB9A (0.48) | KDM4EALDH1A1NPC1HSD17B10ADORA2A | |
| SCHEMBL18848962 | 0.67 | BACE1 (0.38) | KDM4ENPC1GAARAB9AUSP2 | |
| SCHEMBL352098 | 0.67 | KDM4E (0.68) | KDM4EALDH1A1ERCC1DNASE1FEN1 | |
| SCHEMBL27905061 | 0.66 | KDM4E (0.39) | KDM4EALDH1A1NPC1HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193225-B2 | Isoxazole amides, derivatives and methods of chemical induction of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090036451-A1 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036451-A1 | Chemical inducers of neurogenesis | DCX, NES, GAP43 | KDM4E 2440/4885ALDH1A1 415/4885ERCC1 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.