Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12224721 | 0.85 | KDM4E (0.68) | KDM4EHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL23792544 | 0.83 | KDM4E (0.73) | KDM4EHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL27906338 | 0.82 | KDM4E (0.78) | KDM4EHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL656958 | 0.81 | KDM4E (1.00) | KDM4EHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL13638811 | 0.80 | RAB9A (0.63) | KDM4EHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL3065986 | 0.80 | KDM4E (0.73) | KDM4EHPGDRAB9ANPC1POLB | |
| SCHEMBL2691717 | 0.80 | KDM4E (0.73) | KDM4EHPGDALDH1A1RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL6822052 | 0.80 | KDM4E (0.97) | KDM4EHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL25474267 | 0.79 | KDM4E (0.68) | KDM4EHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL10851498 | 0.78 | HPGD (1.00) | HPGDRAB9ANPC1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365927-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2023-11-16 | — | — | US | claimed |
| EP-4230731-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | Institute Of Zoology, Chinese Academy Of Sciences (CN) | 2023-08-23 | — | — | EP | claimed |
| CN-114369572-A | Composition and method for transdifferentiating non-neuronal cells into neurons | 中国科学院动物研究所 | 2022-04-19 | — | — | CN | claimed |
| US-20230365927-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2023-11-16 | — | — | US | disclosed |
| EP-4230731-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | Institute Of Zoology, Chinese Academy Of Sciences (CN) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022077549-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | 中国科学院动物研究所 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369572-A | Composition and method for transdifferentiating non-neuronal cells into neurons | 中国科学院动物研究所 | 2022-04-19 | — | — | CN | disclosed |
| US-8148380-B2 | Antibacterial amide and sulfonamide substituted heterocyclic urea compounds | CRESTONE, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20120015941-A1 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds | CRESTONE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015941-A1 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds | NAAA, AADAC, RPSA | KDM4E 1862/4885HPGD 1814/4885ALDH1A1 2806/4885 |
| US-20230365927-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | MYO1B, MYH14, MYO3A | KDM4E 1467/4885HPGD 1854/4885ALDH1A1 1553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.