Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496591 | 0.78 | PTGDR (0.70) | PTGDR | |
| SCHEMBL9912239 | 0.72 | PTGDR (0.63) | NPC1MTORRAB9ASIRT2PTGDR | |
| SCHEMBL13895137 | 0.71 | PTGDR (0.64) | PTGDRALDH1A1SMN1; SMN2KDM4EF13A1 | |
| SCHEMBL13895143 | 0.71 | ALDH1A1 (0.55) | RAB9APTGDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9912208 | 0.71 | PTGDR (0.57) | PTGDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9912204 | 0.70 | PTGDR (0.56) | PTGDRALDH1A1SMN1; SMN2 | |
| SCHEMBL13895136 | 0.70 | PTGDR (0.61) | NPC1MTORRAB9ASIRT2PTGDR | |
| SCHEMBL13895060 | 0.70 | PTGDR (0.61) | PTGDRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9912237 | 0.70 | PTGDR (0.52) | PTGDRALDH1A1SMN1; SMN2 | |
| SCHEMBL13894988 | 0.70 | CNR2 (0.44) | NPC1MTORRAB9ASIRT2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193183-B2 | 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists | AVENTIS PHARMACEUTICALS INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-7517889-B2 | 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists | AVENTIS PHARMACEUTICALS, INC. (US) | 2009-04-14 | — | — | US | disclosed |