Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 3/20 | 0.63 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9912208 | 0.78 | PTGDR (0.57) | PTGDRPIK3CAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4502924 | 0.78 | PTGDR (1.00) | PTGDRCNR2TRPV1 | |
| SCHEMBL9912183 | 0.72 | NPC1 (0.51) | PTGDRALDH1A1SMN1; SMN2NPC1KDM4E | |
| SCHEMBL13895140 | 0.72 | PTGDR (0.60) | PTGDRPIK3CAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13894988 | 0.72 | CNR2 (0.44) | PTGDRCNR2TRPV1PIK3CAALDH1A1 | |
| SCHEMBL13894999 | 0.71 | ALDH1A1 (0.47) | PTGDRPIK3CAALDH1A1SMN1; SMN2PIK3CB | |
| SCHEMBL9912276 | 0.71 | PTGDR (0.63) | PTGDRPIK3CAALDH1A1SMN1; SMN2PIK3CB | |
| SCHEMBL13895136 | 0.70 | PTGDR (0.61) | PTGDRCNR2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9912189 | 0.70 | BCHE (0.47) | PTGDRPIK3CAALDH1A1SMN1; SMN2PIK3CB | |
| SCHEMBL9912204 | 0.70 | PTGDR (0.56) | PTGDRPIK3CAALDH1A1SMN1; SMN2PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193183-B2 | 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists | AVENTIS PHARMACEUTICALS INC. (US) | 2012-06-05 | — | — | US | disclosed |