⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5980626 | 0.79 | TSHR (0.33) | — | |
| SCHEMBL5977272 | 0.73 | TSHR (0.33) | — | |
| SCHEMBL14679918 | 0.71 | — | — | |
| SCHEMBL16724660 | 0.71 | TDP1 (0.34) | — | |
| SCHEMBL12390891 | 0.71 | MEN1 (0.33) | — | |
| SCHEMBL6364093 | 0.71 | ACHE (0.31) | — | |
| SCHEMBL14392214 | 0.71 | LMNA (0.33) | — | |
| SCHEMBL12208008 | 0.70 | ACHE (0.44) | — | |
| SCHEMBL18518038 | 0.70 | TSHR (0.32) | — | |
| SCHEMBL4584159 | 0.69 | MEN1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9226932-B2 | Phosphoramidate alkylator prodrugs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2016-01-05 | — | — | US | disclosed |
| US-9187467-B2 | 2-phenyl benzothiazole linked imidazole compounds as potential anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-11-17 | — | — | US | disclosed |
| US-20150141657-A1 | 2-PHENYL BENZOTHIAZOLE LINKED IMIDAZOLE COMPOUNDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-05-21 | — | — | US | disclosed |
| US-20140170240-A1 | Phosphoramidate Alkylator Prodrugs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-8664204-B2 | Phosphoramidate alkylator prodrugs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2014-03-04 | — | — | US | disclosed |
| US-20130303778-A1 | PHOSPHORAMIDATE ALKYLATOR PRODRUGS | THRESHOLD PHARMACEUTICALS, INC. | 2013-11-14 | — | — | US | disclosed |
| US-8507464-B2 | Phosphoramidate alkylator prodrugs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-8278454-B2 | Process for preparing tetrahydroquinoline derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-10-02 | — | — | US | disclosed |
| US-8207345-B2 | Antitumor agents; use in combination with other drugs such as pentamidine | MERCK PATENT GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| US-8198452-B2 | Polymorphic forms and process | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-06-12 | — | — | US | disclosed |
| US-8003625-B2 | Phosphoramidate alkylator prodrugs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-7915416-B2 | Tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2011-03-29 | — | — | US | disclosed |
| US-7893082-B2 | Antitumor agents; anticancer agents | MERCK PATENT GMBH (DE) | 2011-02-22 | — | — | US | disclosed |
| US-20100311976-A1 | PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100137254-A1 | PHOSPHORAMIDATE ALKYLATOR PRODRUGS | IMMUNOGENESIS, INC. | 2010-06-03 | — | — | US | disclosed |
| US-20090176820-A1 | POLYMORPHIC FORMS AND PROCESS | MERCK PATENT GESELLSCHAFT (DE) | 2009-07-09 | — | — | US | disclosed |
| US-20090030028-A1 | Tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2009-01-29 | — | — | US | disclosed |
| US-20080221118-A1 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080200451-A1 | Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5 | MERCK PATENT GMBH (DE) | 2008-08-21 | — | — | US | disclosed |
| US-20080194615-A1 | Antitumor agents; anticancer agents | MERCK PATENT GMBH (DE) | 2008-08-14 | — | — | US | disclosed |