Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.65 |
| ▸ | CASP7 | P55210 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 11/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.53 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2822324 | 0.90 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL998068 | 0.82 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL12111749 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| Rhetsinine SCHEMBL14478778 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| Rhetsinine SCHEMBL31032978 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL272586 | 0.75 | NR1H4 (0.61) | KDM4EALDH1A1LMNACYP3A4ABCG2 | |
| SCHEMBL1000290 | 0.74 | LMNA (0.57) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL6492381 | 0.74 | CDK4 (0.63) | LMNAMTHFD2CDK4CCND1 | |
| SCHEMBL1311759 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL11844405 | 0.74 | MTHFD2 (0.88) | LMNAABCG2ABCB1MTHFD2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198447-B2 | Fused tricyclic compound having aldose reductase inhibitory activity | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2012-06-12 | — | — | US | disclosed |
| US-20100145052-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145052-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | AKR1C4, AKR1C2, AKR1C3 | KDM4E 2311/4885ALDH1A1 45/4885HPGD 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.