Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29874413 | 0.89 | SLC6A2 (0.45) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL9279121 | 0.85 | OXTR (0.43) | EPHX2OXTRSSTR4CYP2D6SLC6A2 | |
| SCHEMBL9279123 | 0.85 | OXTR (0.43) | EPHX2OXTRSSTR4CYP2D6SLC6A2 | |
| SCHEMBL29875175 | 0.82 | KDM4D (0.43) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL9913834 | 0.80 | DRD2 (0.49) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL9913653 | 0.80 | DRD2 (0.49) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL9957209 | 0.79 | BTK (0.50) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL29874623 | 0.79 | PIK3CD (0.41) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL23951710 | 0.79 | KDM1A (0.47) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL9913886 | 0.78 | KMT2A (0.43) | KMT2AL3MBTL1KDM1AMAOBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012072512-A1 | N-CYCLOBUTYL-IMIDAZOPYRIDINE OR -PYRAZOLOPYRIDINE CARBOXAMIDES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-06-07 | — | — | WO | disclosed |