Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9913653 | 1.00 | DRD2 (0.49) | DRD2DRD3RENKMT2AL3MBTL1 | |
| SCHEMBL9913886 | 0.86 | KMT2A (0.43) | DRD2DRD3RENKMT2AL3MBTL1 | |
| SCHEMBL9278580 | 0.82 | P2RX7 (0.42) | KMT2AL3MBTL1EPHX2P2RX7 | |
| SCHEMBL9278476 | 0.82 | P2RX7 (0.42) | KMT2AL3MBTL1EPHX2P2RX7 | |
| SCHEMBL9278473 | 0.82 | P2RX7 (0.42) | KMT2AL3MBTL1EPHX2P2RX7 | |
| SCHEMBL29874413 | 0.81 | SLC6A2 (0.45) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL9913822 | 0.80 | KMT2A (0.42) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL30213340 | 0.79 | KMT2A (0.49) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL9913652 | 0.78 | KMT2A (0.46) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL9913805 | 0.77 | KDM1A (0.47) | KMT2AL3MBTL1KDM1AMAOBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012072512-A1 | N-CYCLOBUTYL-IMIDAZOPYRIDINE OR -PYRAZOLOPYRIDINE CARBOXAMIDES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-06-07 | — | — | WO | disclosed |