Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.47 |
| ▸ | MGLL | Q99685 | 6/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16489106 | 0.95 | PTGS1 (0.39) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL23693015 | 0.90 | ALDH1A1 (0.36) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL9914762 | 0.87 | HTT (0.37) | PTGS1PTGS2ALDH1A1HPGDHTT | |
| SCHEMBL28663867 | 0.86 | PTGS1 (0.48) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL208987 | 0.85 | PRKCA (0.35) | MGLLFAAHALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28667915 | 0.85 | PTGS1 (0.46) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL13227716 | 0.83 | PTGS1 (0.45) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL16863817 | 0.83 | PTGS1 (0.45) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL20375257 | 0.83 | FKBP1A (0.39) | ALDH1A1MAPTMAPK1GAAFKBP1A | |
| SCHEMBL4521199 | 0.83 | PTGS1 (0.42) | PTGS1PTGS2MGLLFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612682-A2 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates | ImmunoGen, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-2596804-A2 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates | ImmunoGen, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| EP-2596803-A2 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates | ImmunoGen, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| EP-1689846-B1 | Conjugates of maytansinoid DM1 with antibody trastuzumab, linked through a non-cleavable linker, and its use in the treatment of tumours | IMMUNOGEN INC (US) | 2013-03-27 | — | — | EP | disclosed |
| US-8198417-B2 | Potent, durable cytotoxic agents; tissue targeted therapy; tumors, autoimmune diseases, graft versus host disease, viral and parasite infections | IMMUNOGEN INC. (US) | 2012-06-12 | — | — | US | disclosed |