Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488438 | 1.00 | MAPK10 (0.37) | MAPK10NPC1RECQLRAB9ASMN1; SMN2 | |
| SCHEMBL12571335 | 0.86 | MAPK10 (0.41) | MAPK10NPC1RECQLRAB9ASMN1; SMN2 | |
| SCHEMBL15096829 | 0.86 | MAPK10 (0.41) | MAPK10NPC1RECQLRAB9ASMN1; SMN2 | |
| SCHEMBL28354658 | 0.80 | MAPK10 (0.38) | MAPK10NPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL22433833 | 0.80 | MAPK10 (0.38) | MAPK10NPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL8294662 | 0.80 | CTSK (0.43) | MAPK10TDP1DGAT1CA1CA2 | |
| SCHEMBL8603435 | 0.80 | CTSK (0.43) | MAPK10TDP1DGAT1CA1CA2 | |
| SCHEMBL16938665 | 0.80 | MAPK10 (0.38) | MAPK10NPC1RECQLRAB9ASMN1; SMN2 | |
| SCHEMBL8603431 | 0.80 | CTSK (0.43) | MAPK10TDP1DGAT1CA1CA2 | |
| SCHEMBL221182 | 0.78 | MAPK10 (0.37) | MAPK10RAB9ATDP1DGAT1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012075048-A2 | HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-06-07 | — | — | WO | disclosed |