Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14124890 | 0.81 | KMT2A (0.48) | ALDH1A1KMT2AMEN1PKMMAPT | |
| SCHEMBL15319662 | 0.80 | CASP3 (0.54) | KMT2AMEN1RAB9A | |
| SCHEMBL15351771 | 0.75 | HPGD (0.46) | ALDH1A1KMT2AMEN1PKMMAPT | |
| SCHEMBL9915307 | 0.74 | RAB9A (0.43) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL15279029 | 0.74 | KMT2A (0.41) | ALDH1A1KMT2AMAPTHPGDTSHR | |
| SCHEMBL15923220 | 0.72 | MAPT (0.62) | ALDH1A1KMT2AMEN1MAPTRECQL | |
| SCHEMBL30036364 | 0.72 | KMT2A (0.46) | KMT2AMAPTHPGDTSHRRAB9A | |
| SCHEMBL3578423 | 0.72 | RAB9A (0.52) | ALDH1A1KMT2AMEN1PKMMAPT | |
| SCHEMBL15350422 | 0.72 | MAPT (0.45) | ALDH1A1KMT2AMEN1PKMMAPT | |
| SCHEMBL15351154 | 0.72 | KMT2A (0.45) | ALDH1A1KMT2AMEN1PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | ALDH1A1 1829/4885KMT2A 608/4885MEN1 2023/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | ALDH1A1 1829/4885KMT2A 608/4885MEN1 2023/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | ALDH1A1 1829/4885KMT2A 608/4885MEN1 2023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.