Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915322 | 0.86 | CYP1A2 (0.34) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL16748752 | 0.85 | TP53 (0.34) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL9915359 | 0.84 | COMT (0.40) | COMTCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL16748757 | 0.83 | S1PR2 (0.33) | ALDH1A1MAPTMEN1NPC1GAA | |
| SCHEMBL12949557 | 0.82 | COMT (0.39) | COMTGAATP53PDE4B | |
| SCHEMBL9915356 | 0.80 | MEN1 (0.33) | ALDH1A1MAPTMEN1NPC1GAA | |
| SCHEMBL15279057 | 0.80 | TP53 (0.33) | ALDH1A1MEN1GAAKMT2AL3MBTL1 | |
| SCHEMBL9915302 | 0.79 | TP53 (0.40) | ALDH1A1TP53 | |
| SCHEMBL9915353 | 0.77 | KMT2A (0.41) | ALDH1A1MAPTNPC1RAB9AKMT2A | |
| SCHEMBL9915301 | 0.77 | TDP1 (0.36) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | COMT 1386/4885CYP1A2 957/4885CYP2C9 975/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | COMT 1386/4885CYP1A2 957/4885CYP2C9 975/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | COMT 1386/4885CYP1A2 957/4885CYP2C9 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.