Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915360 | 0.85 | KDM4E (0.47) | MAPTCYP3A4MEN1LMNAKMT2A | |
| SCHEMBL9915498 | 0.84 | KDM4E (0.44) | MAPTCYP3A4MEN1LMNAKMT2A | |
| SCHEMBL9915460 | 0.84 | CYP1A2 (0.38) | MAPTCYP3A4MEN1NR1I2LMNA | |
| SCHEMBL9915472 | 0.84 | BACE1 (0.41) | MEN1LMNAKMT2ATRPC6HTT | |
| SCHEMBL9915414 | 0.83 | TSHR (0.54) | MAPTCYP3A4MEN1LMNAKMT2A | |
| SCHEMBL9915496 | 0.79 | MAOB (0.48) | MAPTKMT2AHSD17B10KDM4EHPGD | |
| SCHEMBL9915408 | 0.77 | EGLN1 (0.45) | MAPTLMNAHSD17B10KDM4EHPGD | |
| SCHEMBL9915465 | 0.77 | TRPC6 (0.47) | TRPC6HPGDALDH1A1 | |
| SCHEMBL11858290 | 0.76 | SIRT6 (0.43) | MAPTCYP3A4MEN1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL11845874 | 0.75 | SIRT6 (0.42) | MAPTCYP3A4MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | MAPT 3674/4885CYP3A4 929/4885MEN1 2023/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | MAPT 3674/4885CYP3A4 929/4885MEN1 2023/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | MAPT 3674/4885CYP3A4 929/4885MEN1 2023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.