Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18032968 | 0.86 | TRPC6 (0.46) | KDM4EMAPTTSHRALDH1A1MEN1 | |
| SCHEMBL9915365 | 0.85 | MAPT (0.44) | KDM4EMAPTTSHRALDH1A1MEN1 | |
| SCHEMBL9915498 | 0.85 | KDM4E (0.44) | KDM4EMAPTTSHRALDH1A1MEN1 | |
| SCHEMBL9915414 | 0.84 | TSHR (0.54) | KDM4EMAPTTSHRALDH1A1MEN1 | |
| SCHEMBL18031339 | 0.84 | TRPC6 (0.51) | KDM4EMAPTTSHRALDH1A1ALOX15 | |
| SCHEMBL9915408 | 0.81 | EGLN1 (0.45) | KDM4EMAPTALDH1A1LMNARXRA | |
| SCHEMBL11844383 | 0.80 | TSHR (0.49) | KDM4EMAPTTSHRALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL11846398 | 0.79 | TSHR (0.48) | KDM4EMAPTTSHRALDH1A1MEN1 | |
| SCHEMBL9915472 | 0.79 | BACE1 (0.41) | MEN1LMNACYP1A2KMT2AHTT | |
| SCHEMBL9915460 | 0.79 | CYP1A2 (0.38) | KDM4EMAPTALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | KDM4E 2610/4885MAPT 3674/4885TSHR 4478/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | KDM4E 2610/4885MAPT 3674/4885TSHR 4478/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | KDM4E 2610/4885MAPT 3674/4885TSHR 4478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.