Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915484 | 0.89 | MAPT (0.49) | SMYD3POLBALDH1A1LMNAMEN1 | |
| SCHEMBL15279080 | 0.89 | NR1H4 (0.47) | NR1H4PTPN11PLA2G4B | |
| SCHEMBL16748652 | 0.84 | MEN1 (0.42) | SMYD3NR1H4KDM4ELMNAMEN1 | |
| SCHEMBL14124962 | 0.84 | NR1H4 (0.47) | SMYD3NR1H4KDM4EPOLBALDH1A1 | |
| SCHEMBL9915519 | 0.81 | MEN1 (0.44) | SMYD3KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL15279079 | 0.80 | TLR7 (0.45) | NR1H4LMNAMEN1KMT2A | |
| SCHEMBL15279003 | 0.78 | DAO (0.43) | ALDH1A1LMNA | |
| SCHEMBL14124965 | 0.78 | MEN1 (0.47) | SMYD3KDM4EPOLBLMNAMEN1 | |
| SCHEMBL16748804 | 0.77 | NR1H4 (0.46) | NR1H4LMNAKMT2ATP53SMN1; SMN2 | |
| SCHEMBL11365287 | 0.74 | KDM4E (0.60) | NR1H4PTPN1PTPN6PTPN11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | SMYD3 2617/4885NR1H4 277/4885PTPN1 3410/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | SMYD3 2617/4885NR1H4 277/4885PTPN1 3410/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | SMYD3 2617/4885NR1H4 277/4885PTPN1 3410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.