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Cortisone

Cortisone

SCHEMBL991784

C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

nearest known ligand 0.72

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 6/20 0.72
▸ HIF1A Q16665 5/20 0.72
▸ SMN1; SMN2 Q16637 5/20 0.72
▸ SERPINA6 P08185 5/20 0.72
▸ SHBG P04278 4/20 0.72
▸ NR3C1 P04150 4/20 0.72
▸ NR3C2 P08235 4/20 0.72
▸ LMNA P02545 3/20 0.72
▸ CYP3A4 P08684 3/20 0.72
▸ TSHR P16473 3/20 0.72
▸ MAPT P10636 2/20 0.72
▸ NFKB1 P19838 2/20 0.72
▸ BLM P54132 2/20 0.72
▸ CYP2C9 P11712 1/20 0.72
▸ CYP2D6 P10635 1/20 0.72
▸ ALDH1A1 P00352 1/20 0.72
▸ PMP22 Q01453 1/20 0.72
▸ KCNA1 Q09470 1/20 0.72
▸ SLC47A1 Q96FL8 1/20 0.72
▸ SLC22A2 O15244 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cortisone SCHEMBL17165698 0.99 HIF1A (0.71) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Cortisone SCHEMBL5663871 0.94 HSD17B10 (0.69) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Hydrocortisone SCHEMBL5328946 0.92 HIF1A (0.82) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Cortisone SCHEMBL442505 0.90 HIF1A (0.85) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Hydrocortisone SCHEMBL5493693 0.89 HIF1A (0.78) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Cortisone SCHEMBL16815167 0.89 SMN1; SMN2 (0.78) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Hydrocortisone SCHEMBL8570579 0.86 HIF1A (0.78) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Cortisone SCHEMBL9926754 0.85 HSD17B10 (1.00) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Cortisone SCHEMBL6535496 0.85 HSD17B10 (1.00) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG
Epicorticosterone SCHEMBL21168995 0.85 SMN1; SMN2 (1.00) HSD17B10HIF1ASMN1; SMN2SERPINA6SHBG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011003870-A2 MINI-PEGYLATED CORTICOSTEROIDS, COMPOSITIONS INCLUDING SAME, AND METHODS OF MAKING AND USING SAME CREABILIS S.A. (LU) 2011-01-13 — — WO disclosed