Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9918950 | 0.88 | ALDH1A1 (0.46) | ALDH1A1GAAHPGDTRPA1CYP3A4 | |
| SCHEMBL10433969 | 0.82 | MAPT (0.42) | ALDH1A1GAAHPGDCA12CA1 | |
| SCHEMBL27762926 | 0.76 | ALDH1A1 (0.53) | ALDH1A1GAAHPGDCA12CA1 | |
| SCHEMBL29151744 | 0.75 | CYP3A4 (0.44) | ALDH1A1GAAHPGDTRPA1CYP3A4 | |
| SCHEMBL9050536 | 0.74 | MAPT (0.38) | ALDH1A1GAAHPGDTRPA1CYP3A4 | |
| SCHEMBL2454654 | 0.74 | CA12 (0.49) | ALDH1A1GAAHPGDCYP3A4CA12 | |
| SCHEMBL9918951 | 0.73 | CYP3A4 (0.49) | ALDH1A1GAAHPGDTRPA1CYP3A4 | |
| SCHEMBL9918952 | 0.73 | HPGD (0.39) | ALDH1A1GAAHPGDTRPA1CYP3A4 | |
| SCHEMBL9918941 | 0.73 | ALDH1A1 (0.43) | ALDH1A1GAAHPGDTRPA1CYP3A4 | |
| SCHEMBL12005927 | 0.73 | HPGD (0.43) | ALDH1A1GAAHPGDCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334236-B2 | Lactam-based compounds with a urethane or urea functional group, and uses thereof | ISP INVESTMENTS INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-9334236-B2 | Lactam-based compounds with a urethane or urea functional group, and uses thereof | ISP INVESTMENTS INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-20120149861-A1 | LACTAM-BASED COMPOUNDS WITH A URETHANE OR UREA FUNCTIONAL GROUP, AND USES THEREOF | ISP INVESTMENTS LLC | 2012-06-14 | — | — | US | disclosed |
| US-20120149861-A1 | LACTAM-BASED COMPOUNDS WITH A URETHANE OR UREA FUNCTIONAL GROUP, AND USES THEREOF | ISP INVESTMENTS LLC | 2012-06-14 | — | — | US | disclosed |
| WO-2011022457-A1 | LACTAM-BASED COMPOUNDS WITH A URETHANE OR UREA FUNCTIONAL GROUP, AND USES THEREOF | ISP INVESTMENTS INC. (US) | 2011-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149861-A1 | LACTAM-BASED COMPOUNDS WITH A URETHANE OR UREA FUNCTIONAL GROUP, AND USES THEREOF | CUTA, PUF60, PAM | ALDH1A1 1456/4885GAA 3190/4885HPGD 3532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.