Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.58 |
| ▸ | CUL4A | Q13619 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 11/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 5/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL834711 | 0.93 | EEF2K (0.67) | EEF2KCUL4AMEN1KMT2AALDH1A1 | |
| SCHEMBL15572213 | 0.74 | EEF2K (1.00) | EEF2KCUL4AMEN1KMT2AALDH1A1 | |
| SCHEMBL15572039 | 0.72 | CUL4A (1.00) | EEF2KCUL4AMEN1KMT2AALDH1A1 | |
| SCHEMBL15571632 | 0.72 | MEN1 (0.68) | EEF2KCUL4AMEN1KMT2AALDH1A1 | |
| SCHEMBL15571970 | 0.70 | EEF2K (0.63) | EEF2KCUL4AMEN1KMT2AALDH1A1 | |
| SCHEMBL15571207 | 0.65 | CUL4A (1.00) | EEF2KCUL4AMEN1KMT2AALDH1A1 | |
| SCHEMBL9920140 | 0.62 | ALDH1A1 (0.67) | EEF2KCUL4AMEN1KMT2AALDH1A1 | |
| SCHEMBL15572548 | 0.60 | CUL4A (1.00) | EEF2KCUL4AMEN1KMT2AALDH1A1 | |
| SCHEMBL14665761 | 0.58 | HTR2A (0.43) | ALDH1A1TDP1 | |
| SCHEMBL21043625 | 0.58 | MEN1 (1.00) | EEF2KCUL4AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149673-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149673-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | ORAI1, SARAF, RYR2 | EEF2K 1148/4885CUL4A 3621/4885MEN1 3485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.