Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 10/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.63 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.58 |
| ▸ | GALR3 | O60755 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | USP1 | O94782 | 2/20 | 0.56 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13191861 | 0.86 | EGFR (0.58) | AURKARPS6KB1AURKBEGFRNR2F2 | |
| SCHEMBL13170968 | 0.81 | EGFR (0.67) | EGFRNR2F2GALR3RAB9AHTT | |
| SCHEMBL12175974 | 0.81 | RAD52 (0.64) | LMNAUSP1WDR48PDE5AALDH1A1 | |
| SCHEMBL27848528 | 0.81 | AURKA (0.72) | AURKARPS6KB1AURKBEGFR | |
| SCHEMBL8491665 | 0.81 | GALR3 (0.44) | AURKARPS6KB1AURKBEGFRNR2F2 | |
| SCHEMBL8497012 | 0.79 | HTT (0.65) | AURKAEGFRNR2F2GALR3RAB9A | |
| SCHEMBL9430554 | 0.79 | EGFR (0.69) | AURKARPS6KB1EGFRNR2F2GALR3 | |
| SCHEMBL9921507 | 0.78 | EGFR (1.00) | EGFRNR2F2GALR3RAB9AHTT | |
| SCHEMBL666618 | 0.78 | AURKA (1.00) | AURKARPS6KB1AURKB | |
| SCHEMBL9430904 | 0.77 | EGFR (0.68) | AURKARPS6KB1AURKBEGFRNR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | AURKA 1451/4885RPS6KB1 133/4885AURKB 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.