Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.54 |
| ▸ | USP10 | Q14694 | 1/20 | 0.54 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.54 |
| ▸ | USP13 | Q92995 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921372 | 0.88 | HTT (0.62) | HTTUSP10PIK3C3USP13PIK3CD | |
| SCHEMBL7411782 | 0.85 | HTT (0.52) | HTTCLK4PIK3CDPIK3R1MAPK1 | |
| SCHEMBL13191856 | 0.85 | HTT (0.67) | HTTUSP10PIK3C3USP13PIK3CD | |
| SCHEMBL9921376 | 0.85 | HTT (0.60) | HTTCLK4USP10PIK3C3USP13 | |
| SCHEMBL8482300 | 0.84 | HTT (0.67) | HTTPIK3CDPIK3R1MAPK1LMNA | |
| SCHEMBL9921370 | 0.83 | MAPK1 (0.59) | HTTCLK4USP10PIK3C3USP13 | |
| SCHEMBL9921350 | 0.83 | HTT (0.58) | HTTCLK4USP10PIK3C3USP13 | |
| SCHEMBL7418430 | 0.82 | EGFR (0.61) | CLK4MAPK1CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL9921375 | 0.82 | HTT (0.65) | HTTUSP10PIK3C3USP13PIK3CD | |
| SCHEMBL9921352 | 0.80 | HTT (0.81) | HTTUSP10PIK3C3USP13PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | HTT 4078/4885CLK4 2339/4885USP10 1695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.