Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 10/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.58 |
| ▸ | LMNA | P02545 | 10/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | TSHR | P16473 | 8/20 | 0.58 |
| ▸ | USP2 | O75604 | 8/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483285 | 0.87 | APP (0.68) | MAPK1CYP1A2CYP3A4CYP2D6LMNA | |
| SCHEMBL9921376 | 0.86 | HTT (0.60) | MAPK1CYP1A2CYP3A4CYP2D6LMNA | |
| SCHEMBL9921372 | 0.85 | HTT (0.62) | MAPK1CYP1A2CYP2D6LMNAHTT | |
| SCHEMBL13191856 | 0.83 | HTT (0.67) | MAPK1LMNAHTTEGFRAPP | |
| SCHEMBL9921371 | 0.83 | HTT (0.60) | MAPK1CYP1A2CYP3A4CYP2D6LMNA | |
| SCHEMBL9921350 | 0.81 | HTT (0.58) | MAPK1CYP1A2CYP3A4CYP2D6LMNA | |
| SCHEMBL9921375 | 0.80 | HTT (0.65) | MAPK1CYP1A2CYP2D6LMNAHTT | |
| SCHEMBL9921359 | 0.80 | HTT (0.72) | MAPK1LMNACLK4HTTEGFR | |
| SCHEMBL8498739 | 0.80 | LDHA (0.57) | MAPK1CYP1A2CYP3A4CYP2D6LMNA | |
| SCHEMBL9921373 | 0.80 | CLK4 (0.63) | MAPK1CYP1A2CYP3A4CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | MAPK1 310/4885CYP1A2 4274/4885CYP3A4 4069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.