Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013155 | 0.82 | LMNA (0.55) | LMNAALDH1A1THRB | |
| SCHEMBL11791931 | 0.78 | LMNA (0.50) | LMNATHRB | |
| SCHEMBL1275928 | 0.78 | LMNA (0.50) | LMNATHRB | |
| SCHEMBL575530 | 0.78 | ALDH1A1 (0.65) | LMNAALDH1A1USP2TSHR | |
| SCHEMBL13430496 | 0.77 | THRB (0.50) | LMNAALDH1A1THRBUSP2TSHR | |
| SCHEMBL15475634 | 0.76 | LMNA (0.48) | LMNATHRBTSHR | |
| Ammonia Solution, Strong SCHEMBL18730207 | 0.76 | LMNA (0.48) | LMNATHRB | |
| Lithium Ion SCHEMBL17456395 | 0.76 | LMNA (0.48) | LMNATHRB | |
| SCHEMBL10671296 | 0.76 | TSHR (0.39) | ALDH1A1TSHR | |
| SCHEMBL11791947 | 0.75 | LMNA (0.46) | LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104402773-A | Process for the preparation of 2-methyl-2' -phenylpropionic acid derivatives and intermediate compounds | YUHAN CORP | 2015-03-11 | — | — | CN | disclosed |
| CN-101952273-B | Process for the preparation of 2-methyl-2' -phenylpropionic acid derivatives and intermediate compounds | YUHAN CORP | 2014-11-12 | — | — | CN | disclosed |
| US-8633223-B2 | Process for preparation of 2-methyl-2′-phenylpropionic acid derivatives and novel intermediate compounds | YUHAN CORPORATION (KR) | 2014-01-21 | — | — | US | disclosed |
| US-8487106-B2 | Process for preparation of 2-methyl-2′-phenylpropionic acid derivatives and novel intermediate compounds | YUHAN CORPORATION (KR) | 2013-07-16 | — | — | US | disclosed |
| US-20130116466-A1 | PROCESS FOR PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | YUHAN CORPORATION (KR) | 2013-05-09 | — | — | US | disclosed |
| US-8367704-B2 | Process for preparation of 2-methyl-2′ phenylpropionic acid derivatives and novel intermediate compounds | YUHAN CORPORATION (KR) | 2013-02-05 | — | — | US | disclosed |
| CN-101952273-A | Process for the preparation of 2-methyl-2' -phenylpropionic acid derivatives and novel intermediate compounds | YUHAN CORP | 2011-01-19 | — | — | CN | disclosed |
| US-20110009636-A1 | PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | YUHAN CORPORATION (KP) | 2011-01-13 | — | — | US | disclosed |
| US-4988714-A | Drugs for treatment of obesity and diabetics, increases protein breakdown, for fattening animals | HOFFMANN-LA ROCHE INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0375076-A1 | Heterocyclic herbicides | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-06-27 | — | — | EP | disclosed |
| CN-1005711-B | Preparation method of phenoxypropanolamine compounds | 弗·哈夫曼-拉罗彻公司 | 1989-11-08 | — | — | CN | disclosed |
| US-4800206-A | ANTIDIABETIC AGENTS; HYPOGLYCEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-01-24 | — | — | US | disclosed |
| CN-85101280-A | Benzene oxygen propanol amine compounds | — | 1987-01-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009636-A1 | PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | HRH4, HCAR2, HRH1 | LMNA 3800/4885ALDH1A1 133/4885THRB 3478/4885 |
| US-20130116466-A1 | PROCESS FOR PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS | HRH1, HRH2, HRH4 | LMNA 3859/4885ALDH1A1 192/4885THRB 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.