Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15070157 | 0.87 | SIGMAR1 (0.47) | MEN1KMT2ASIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL1595230 | 0.84 | MTOR (0.44) | PPARGPPARANPC1RAB9AMTOR | |
| SCHEMBL4300599 | 0.84 | MTOR (0.44) | PPARGPPARANPC1RAB9AMTOR | |
| SCHEMBL15070151 | 0.75 | SIGMAR1 (0.41) | MEN1KMT2ASIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL45416 | 0.75 | SIGMAR1 (0.46) | MEN1KMT2ASIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL4297563 | 0.72 | MTOR (0.49) | PPARGPPARAMTORMEN1KMT2A | |
| SCHEMBL4297567 | 0.72 | MTOR (0.49) | PPARGPPARAMTORMEN1KMT2A | |
| SCHEMBL1594664 | 0.72 | NOS3 (0.47) | PPARGPPARAMTORMEN1KMT2A | |
| SCHEMBL1594667 | 0.72 | NOS3 (0.47) | PPARGPPARAMTORMEN1KMT2A | |
| SCHEMBL1594425 | 0.71 | PPARG (0.44) | PPARGPPARANPC1RAB9AMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-B1 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | AMGEN INC (US) | 2012-06-13 | — | — | EP | disclosed |