Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17206624 | 1.00 | CYP2D6 (0.44) | CYP2D6SLC6A9SLC6A5L3MBTL1RAB9A | |
| SCHEMBL9924131 | 0.90 | NPC1 (0.50) | CYP2D6L3MBTL1RAB9ANPC1GRM5 | |
| SCHEMBL17206620 | 0.89 | GRM4 (0.39) | CYP2D6SLC6A9SLC6A5RAB9ANPC1 | |
| SCHEMBL9924215 | 0.89 | SLC6A9 (0.41) | CYP2D6SLC6A9SLC6A5RAB9ANPC1 | |
| SCHEMBL9924260 | 0.85 | MEN1 (0.46) | CYP2D6L3MBTL1RAB9ANPC1MEN1 | |
| SCHEMBL9924261 | 0.84 | TRPV1 (0.42) | CYP2D6SLC6A9MEN1KMT2AEPHX2 | |
| SCHEMBL9924333 | 0.84 | NPC1 (0.44) | L3MBTL1RAB9ANPC1GRM5MEN1 | |
| SCHEMBL9924130 | 0.82 | DCUN1D1 (0.52) | CYP2D6MEN1KMT2ALMNAEPHX2 | |
| SCHEMBL9924214 | 0.82 | MEN1 (0.49) | CYP2D6L3MBTL1RAB9ANPC1MEN1 | |
| SCHEMBL9924457 | 0.82 | NPC1 (0.43) | RAB9ANPC1GRM5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |